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While treatment for schizophrenia up until now has focused on blocking dopamine signaling across the brain, Cobenfy targets the M1 and M4 muscarinic receptors

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GIPR agonists decrease food intake and body weight in mice through a pathway involving Gipr -expressing GABAergic neurones, a population of which has been located in the area postrema (AP) of the brainstem 4,5,6

The SASP damages surrounding tissue, drives chronic inflammation, and converts neighboring healthy cells into senescent ones (van Deursen, 2014)