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Then, in 2015, Lee and colleagues identified a previously overlooked open reading frame within the 12S ribosomal RNA gene of mtDNA and found that it encodes a functional peptide, MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA-c) [1]

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MM: Formal Analysis, Writingoriginal draft

It was found that 48-h exposure to rotenone significantly increased Ca 2+ content, indicated by Fluo3(i) fluorescence, and increased ceramide content, decreased cell size measured as FSC, and increased annexin V binding

Impairment of glymphatic clearance is associated with A plaque deposition in APP-PS1 mice Two-photon imaging revealed fibrillar amyloid plaques in the parenchyma, but no evidence of CAA in 78-month-old APP-PS1 mice (Fig