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After 8 weeks of the HFD, the HFD + NaB group underwent daily intragastric administration of NaB at 200 mg/kg body weight for 8 weeks, while the HFD group received the same amount of saline daily for 8 weeks

The fasting treatment consisted of 2 days with moderate calorie restriction (700800 Kcal/day), 5 days of intense calorie restriction (200 Kcal/day), followed by 3 days with the stepwise reintroduction of a normal diet

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