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DHA was discovered as a skin-browning agent in the 1920s, when healthcare providers noticed localized skin darkening in children being treated orally with DHA for glycogen storage disease

doi: 10.1007/s00384-014-2030-8.

Mol Endocrinol 11(13):19241933 Hastie PM, Haresign W (2006) Expression of mRNAs encoding insulin-like growth factor (IGF) ligands, IGF receptors and IGF binding proteins during follicular growth and atresia in the ovine ovary throughout the oestrous cycle

Most people see a decline in blood sugar levels within the first week of treatment

However, the molecular mechanism by which betaine increases blood cholesterol concentrations is yet to be explored