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High-dose BBR treat diabetic symptoms, but its associated with significant gastrointestinal side effects (Kuma et al., 2019) and cardiovascular system side effects (Martini et al., 2020)

Peptides 15: 675-681, 1994

The most commonly reported side effects when taking Neo-B12 Injection include Itching, exanthema (widespread rash), diarrhoea, nausea, vomiting, dizziness, headache, acne, eczematous skin lesions, acne and folliculitis

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SMIT1 and SMIT2 both have a different affinity for inositol isomers, which are competitors for inositol transport, and are differentially regulated by monosaccharides