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Diarrhea, nausea, and vomiting may cause a loss of fluids (dehydration), which may cause kidney problems

Crocin protects the renal tubular epithelial cells against high glucose-induced injury and oxidative stress via regulation of the SIRT1/Nrf2 pathway

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[1] [6] Common dosing protocols in clinical studies have ranged from 600 mg to 1,400 mg per session, administered two to three times per week, though higher or lower doses may be used depending on individual needs