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Animal acute toxicity studies across Sikiric's group publications have consistently shown a low acute toxicity profile, with no defined lethal dose identified in standard rodent models

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doi: 10.2174/1574892817666220905114120 93 HeXZhouYChenWZhaoXDuanLZhouHet al

The remaining tumor and metastases following chemotherapy can often lead to tumor recurrence (7,8)