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The enzyme contains, at its catalytic centre, an amino acid that the standard genetic code did not appear to encode

Maintain standard laboratory handling procedures

The 2024 fusion-peptide work exists precisely because researchers recognized that native DSIPs delivery to the brain is the bottleneck, and engineered around it by fusing DSIP to a blood-brain-barrier-crossing TAT transduction domain (sequence GGGGYGRKKRRQRRR) via flexible GGGGS linkers, expressed and secreted from Pichia pastoris

Peptides are short chains of amino acids that act as signaling molecules in the body, as the National Library of Medicine explains in its overview of how proteins and peptides function