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In the world of pharmacology, there is a concept called the therapeutic window. This is the dosage range where a drug provides the maximum benefit with the minimum risk of side effects

doi: 10.1016/j.immuni.2015.05.018 69 DeRubertisBGStilesBMBhargavaAGusaniNJHezelMDAngelicaMet al

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Debarbieux S, Depaepe L, Poulalhon N, et al

In an interview with InStyle , celebrity stylist Danny Moon explained that the reason why red is such a hard color to maintain is because the dye molecules are larger than other hues, making it more difficult to penetrate hair strands than colors with smaller molecules