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Research published in Gastroenterology demonstrated that nanomolar concentrations of KPV inhibit NF-kB and MAP kinase inflammatory signaling pathways through PepT1-mediated transport, and reduce pro-inflammatory cytokine secretion

Nat Commun 12:5862

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Mechanistic investigations clarify this selective recovery signaling: Selective somatotroph targeting reduces activation of ACTH-secreting corticotroph cells In vitro pituitary assays show preserved GH release with negligible prolactin secretion Comparative endocrine panels confirm minimal cortisol elevation relative to hexarelin or GHRP-6 Moreover, receptor-binding analyses [3] indicate that ipamorelin demonstrates high affinity for GHSR-1a without broad engagement of alternative pituitary receptor systems