While transplant-free survival is improving with better medical management, deciding who truly requires liver transplantation has become more complex due to the growing success of intensive care and NAC therapy
These include small-molecule inhibitors such as Fer-1 [35, 46, 47, 50, 51, 55, 75, 95, 97, 110, 115, 119, 134, 137, 138], liproxstatin-1 [41, 55, 98], deferoxamine (DFO) [98, 138], and N-acetylcysteine (NAC) [35, 137], as well as GPX4 activators [52] that restore cellular redox balance
During the production process, temperature and humidity must be strictly controlled
This hypermetabolic state results in enhanced glycolysis and increased ROS production, exacerbating oxidative stress
The protein exhibited weak oxidoreductase activity in the HED assay