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Always consult a licensed provider before starting or changing weight-loss medication.

These typically improve gradually as drug levels decline, though some patients report a temporary worsening of nausea during the first week after discontinuation before improvement occurs

doi:10.1016/S2213-8587(25)00027-0

Combined use of both compounds is entirely unstudied in humans and carries unpredictable metabolic and cardiovascular risks

Specific symptoms that should prompt medical consultation include an irresistible urge to move the legs, especially when accompanied by uncomfortable sensations such as crawling, pulling, tingling, or aching deep within the leg muscles