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While there may be some resistance to the conduction of clinical trials of pharmacological interventions in these clinical populations, the mechanistic profile of GLP-1RAs clearly suggests that these medications may play a role in the treatment of certain specific eating disorders, such as BED
N.KingS
Preclinical studies suggest good tolerability, but comprehensive human trials are needed to establish safety profiles
Endogenous synthesis of lipoic acid The figure illustrates the mitochondrial de novo synthesis of lipoic acid, starting with the formation of octanoic acid in the acyl-carrier protein (ACP)-dependent fatty acid synthesis pathway
It can lead to reduced ovarian reserve and impaired oocyte quality
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