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The importance of GLP-1 is demonstrated in experiments showing that it accounts for up to 60% of postprandial insulin secretion in healthy individuals

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In a model of cognitive decline associated with diabetes, BBR treatment decreases levels of inflammatory factors such as IL-6, iNOS, and TNF-, increases acetylcholine levels and permeability of the blood-brain barrier, thereby improving cognitive performance in mice (Gupta et al., 2025)

Acknowledgements The authors receive support from NIH grants CA121277, CA91956, and CA125747

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