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GLP-1RAs ameliorate ROS-induced or hyperglycemia-induced apoptosis through modulating IL-6 production and ER stress-induced by hyperhomocysteinemia, via stromal cell-derived factor (SDF)-1/C-X-C motif receptor 7 (CXCR7) -AMPK/p38-MAPK axis [113-115]
These two drugs may be preferred, for example, in patients with both diabetes and significant obesity, and those who need an extended course to lose weight
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Ibuprofen, particularly in regular doses, inhibits protective prostaglandins in the stomach, increasing ulcer risk under normal circumstancesa concern that may be amplified in patients whose GI tract is already adjusting to a new medication
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