People with chronic kidney or liver disease can accumulate B12 due to lower detoxification function when these organs are impaired
Furthermore, VEGF may also increase the permeability of blood vessels, which might enable the extravasation of plasma proteins and contribute to the formation of a primitive vascular scaffold, thereby potentially promoting the process of angiogenesis
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8,9 Table 1 Risk Factors for Vitamin B12 Deficiency A multicenter randomized controlled trial of 390 patients with diabetes mellitus showed that those taking 850 mg of metformin three times per day had an increased risk of vitamin B 12 deficiency (number needed to harm = 14 per 4.3 years) and low vitamin B 12 levels (number needed to harm = 9 per 4.3 years) vs