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This reactivation triggers the transcription of the antioxidant gene SOD2, which helps counteract ROS-induced stress and supports wound healing under diabetic conditions

This paper reviews the regulatory effects of metformin on the gut microbiota, such as increasing the abundance of genus Akkermansia , enriching short-chain fatty acids (SCFAs)-producing bacterial genus, and regulating gene expression of certain genera

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Glutamate is the most important transmitter for normal brain function, but excessive glutamate may cause toxic damage to the brain