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Interestingly, among the CV outcomes trials with SGLT2 inhibitors, the EMPA REG OUTCOME trial, in which almost all patients had a history of CV events at baseline, showed marked reduction in all-cause mortality and CV death [1]

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Older people with severe kidney disease (who are not on dialysis) are an exception to this rule these individuals may need to limit their protein intake, as their kidneys may not be able to properly process the protein