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Novel pathway for LPS-induced afferent vagus nerve activation: Possible role of nodose ganglion

Five serum autoantibodies are indicative of humoral immunity in LADA: glutamic acid decarboxylase autoantibody (GADA) (one of the most sensitive immunological criteria for diagnosing LADA), pancreatic islet-cell antibodies (ICA), insulinoma associated-2 autoantibodies (IA-2 A), autoantibodies against insulin (IAA), and an association of zinc transporter-8 autoantibody (ZnT8A)

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The four-pathway model therefore targets appetite (GLP-1 and amylin through separate neuronal circuits), fat metabolism (GIP and glucagon), energy expenditure (glucagon primarily), and glucose homeostasis (GLP-1, GIP, and amylin all contribute through different mechanisms)