Notably, N259 and E255 in the C1 region are critical residues
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BRD4 Proteolysis Targeting Chimera (PROTAC) ARV-825 targets both NOTCH1-MYC regulatory circuit and leukemia-microenvironment in T-ALL
These stem cells have the ability to differentiate into different cell types dependent on the environment into which they are injected, such as tendons, joints and ligaments
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