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Mice were single-housed and transferred to Promethion Metabolic chambers (Sable Systems International) at the Vanderbilt Mouse Metabolic Phenotyping Center (VMMPC) and acclimated for 3 days (for mice at RT) to 6 days (for mice at TN)

Further optimization of the timing, dose, and duration of IGF-1R mAb treatment is warranted in order to maximize benefits while minimizing risks, particularly given recent evidence that transient administration of other drugs can have persistent benefits on age-related outcomes 43

Pricing Disclaimer: The $179 price referenced represents the starting price for the first month of treatment

Repetitive behavior as assessed through percentage of marbles buried over a thirty-minute period was comparable between the control and MIA mice, with an average of 50.2 5.8 percent buried by control mice and 48.9 6.3 percent buried by MIA mice

The intersection target data were imported into the DAVID database, 17 and GO and KEGG enrichment analyses (Chen J