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(2014) Safety and efficacy of intravenous ultra-high dose methylcobalamin treatment for peripheral neuropathy: a phase I/II open label clinical trial

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We found that 2A -adrenergic receptor activation by DA or NE results in G i1 recruitment to the receptor, with NE showing higher potency (EC 50 = 520 1.4 nM) and efficacy compared to DA (EC 50 = 2.1 0.002 M

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