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Poly (ADP-ribose) polymerase (PARP) is a major repair mechanism resolving DNA lesions caused by endogenous processes, including oxidative stress in spermatocytes (Agarwal et al., 2009), and plays a key role in a wide range of testis-associated processes, including maintenance of genomic stability, transcriptional regulation, centromere function and mitotic spindle formation, trafficking of endosomal vesicles, apoptosis, and necrosis (Omar et al., 2018)

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A missed dose is not catastrophic, but repeated misses undermine the protocol

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