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Oxidative stress has been identified as having an important role in cerebrovascular disease and given increasing recognition of the overlap between vascular dementia and AD (mixed dementia) and the contribution of vascular changes to AD [93] investigating potential effects of cerebrovascular disease as a covariate would be an important direction for future studies

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(3) Hemodynamic Effects: Combined and effects result in a marked increase in cardiac output, decreased diastolic blood pressure, and reduced peripheral resistance, including vasodilation in skeletal muscle