A randomized, placebo-controlled trial
Lucena MI, Andrade RJ, de la Cruz JP, Rodriguez-Mendizabal M, Blanco E, Snchez de la Cuesta F
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In order to elucidate the target for free inositols, we propose an in vitro study of cultured hepatocytes or myocytes, as highly-responsive cells to insulin stimulus, and the blockade, one by one, of elements composing the cascade of the insulin signaling pathway (IR, IRS1, PI3K, PDK, Akt, mTOR, and AMPK) in a top-down manner