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doi: 10.1126/science.2471267 32 RasmussenMHarndahlMStryhnABouchermaRNielsenLLLemonnierFAet al

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Figure 4 In the context of gout, a decrease in BA levels leads to attenuated FXR activity, consequently diminishes the inhibitory effect on NLRP3 and NF-B signaling pathways and promotes enhanced activity and expression of intestinal XOD, thereby triggering inflammatory responses and elevated UA levels, which exacerbate the progression of gout ( Figure 4 )