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Fukagawa NK, Martin JM, Wurthmann A, Prue AH, Ebenstein D, and O'Rourke B (2000)

That makes it unclear whether the association reflected alpha-ketoglutarate itself, the delayed-release formulation, the added vitamins, or other differences among users

The proposed mechanism involves the matrix metalloproteinase activity that breaks down old collagen faster than new collagen replaces it

Li W et al., J Pain Res 2020 Methylcobalamin for post-herpetic neuralgia meta-analysis

Side Effects & Safety Current knowledge of Dihexa's safety profile is primarily based on animal studies, with no formal human safety data available