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DSIP has a very short plasma half-life of approximately 5 to 8 minutes in peripheral blood due to rapid enzymatic degradation by endopeptidases

There are several major redox participants that reflect redox state (Jones and Sies, 2015): NAD + , NADP + , oxidized glutathione (GSSG), thioredoxin (Trx ox ) and peroxiredoxin (Prx ox ) in the oxidized forms, and NADH, NADPH, glutathione (GSH), Trx and Prx, in the reduced form (Figure 1)

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