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There is also some evidence that ADSL deficiency may lead to altered cerebral energy metabolism through the interactions between fumarate and AMP with purines (80)

Iran J Kidney Dis 9:221 Kobara M, Tatsumi T, Kambayashi D, Mano A, Yamanaka S, Shiraishi J, Keira N, Matoba S, Asayama J, Fushiki S (2003) Effects of ACE inhibition on myocardial apoptosis in an ischemiareperfusion rat heart model

On the pathological side, intestinal dysbiosis and compromised barrier integrity may allow pathogenic bacteria (e.g., Fusobacterium ) to enter the systemic circulation

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