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CSF examination also shows elevated lactate levels in addition to low homovanillic acid (HVA), along with high levels of 3-O-methyldopa, levodopa, and 5-hydroxytryptophan, suggesting the dysfunction of aromatic L-amino acid decarboxylase (AADC)
Fractionation of this sleep-promoting blood eventually yielded a small nine-amino acid peptide that could reproduce these effects, and Monnier and colleagues published their findings in 1977, entering the compound into the scientific literature as Delta Sleep-Inducing Peptide
Deficiency of this substance inhibited senescence escape in the majority of examined cell lines [49]
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