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risks associated with Skye's common stock and the other important factors discussed under the caption "Risk Factors" in Skye's filings with the Securities and Exchange Commission, including in its Annual Report on Form 10-K for the year ended December 31, 2024, which are accessible on the SEC's website at www.sec.gov and the Investors section of Skye's website

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Phentermine has been used for short-term weight management (typically 12 weeks or less) since 1959, while GLP-1 agonists like Ozempic and Mounjaro gained obesity indication approval only in 2021 and 2023 respectively, backed by multi-year trial data

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Contrave is taken as a twice-daily tablet, gradually increased to the full dose over several weeks