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If diarrhoea is accompanied by fever, blood in stools, severe abdominal pain, or dehydration, an infectious or inflammatory cause should be considered and medical attention sought promptly

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This phenomenon is further complicated by reported no observed adverse effect levels (NOAELs) that vary by 23 orders of magnitude across studies, likely reflecting differences in metabolic processing, genetic susceptibility, and methodological approaches (9)

Additionally, because low NAD+ is linked to aging, its decline could contribute to the development of various age-related health concerns, including cardiovascular disease, metabolic disorders, the development of neurodegenerative diseases such as Alzheimers and Parkinsons, and cancer