Semaglutide and other GLP1R agonists have transformed the treatment landscape for obesity and type 2 diabetes, primarily through their appetite-suppressing and weight-reducing actions
The FDA-approved dosing includes gradual titration specifically to minimize adverse effects
6,14 Furthermore, GLP-1 signaling indirectly enhances and restores the insulin signaling pathway in neurons, leading to a reduction in the phosphorylation of insulin receptor substrates and the burden caused by monomeric -synuclein
*Correspondence: Parisa Alsadat Dadkhah, [email protected] These authors have contributed equally to this work Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers
Given the suspicion for rhabdomyolysis and timing associated with semaglutide initiation, administration of the drug was discontinued