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Disruption of this barrier permits microbial translocation into the submucosa, triggering inflammatory cascades that contribute to the pathogenesis of intestinal disorders such as IBD (159)

Clin Neurol Neurosurg 196:106018 Wang M, Xie Y, Qin D (2021a) Proteolytic cleavage of proBDNF to mBDNF in neuropsychiatric and neurodegenerative diseases

doi: 10.3389/fimmu.2020.617089 88 ChenYXuZWangPLiXMShuaiZWYeDQet al

Drugs in this group include metformin and myoinositol (137)

Menstrual irregularities An analysis of over 410,000 social media posts (self-reported anecdotal evidence) by people taking semaglutide or tirzepatide found that menstrual irregularities were among the most commonly self-reported side effects not well captured in clinical trial data, suggesting this may be more prevalent than official labelling indicates