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Alkylation base damage is converted into repairable double-strand breaks and complex intermediates in G2 cells lacking AP endonuclease

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Like the binding mode for GSH, CP17 is bound within the VP1VP3 interprotomer pocket of the wt PV2 VLP through two critical arginine residuesArg243 and Arg258from neighbouring VP1 subunits, which form hydrogen bonds and salt-bridges with the carboxylate group of CP17 (Fig