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These materials are difficult to degrade naturally and may accumulate in aquatic or terrestrial ecosystems, posing risks to microbial communities, plants, and animals

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10.3389/fcell.2019.00262 25 NavarreteF

Stomach acid and an enzyme called gamma-glutamyl transferase (GGT) break down glutathione before it can reach the small intestine for absorption.[4] The research on this is brutally clear: A 1992 study gave participants a single 3-gram dose of oral glutathione thats ten times what most supplements contain