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The existence of this correlation is supported by preclinical studies in mouse xenograft models, which showed that the therapeutic inhibition of angiogenesis reduces tumor vascularization and causes hypoxia, and therefore may promote c-Met-mediated invasion of malignant cells [50]

PT-141 also boosts norepinephrine, which can also enhance mood (4)

Higher doses cause more inhibition in this dose-dependent effect

This results in decreased blood sugar spikes