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For CJC-1295 specifically, the most direct human evidence is endocrine: increased GH and IGF-1, particularly with the DAC-modified analog. Why it matters: CJC-1295 is relevant to body-composition research because it activates a pathway involved in lean tissue signaling, fat metabolism, and tissue remodeling

GHRH analogs like Tesamorelin and Sermorelin were developed precisely to address this deficiency by stimulating the pituitary glands own GH output, preserving the bodys endocrine feedback loop rather than bypassing it

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