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We propose that AtSNX1 drives the formation of spherical structures due to its limited ability to bind to and stabilize tubules, thereby preventing the formation of elongated tubular structures

VacA exerts multiple effects on epithelial cells resulting in the induction of vacuole formation in the gastric epithelial cellular membrane, cellular damage, an increase of intracellular permeability and the modulation of apoptosis rather than release of pro-inflammatory cytokines (see Fig