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A crucial role of lactate accumulation in cancer cells has been demonstrated regarding its ability to induce expression of anti-inflammatory and proangiogenic genes, together with the modification of histones through a process called lactylation, where a lactyl-CoA is added to lysine residues present in the tails of histones [33]

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The delivery method can also influence how these benefits are experienced, with injectable forms often providing stronger and more consistent outcomes, while nasal sprays may offer a more accessible entry point