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Although our experience suggests that hydroxocobalamin does not cause clinically significant interference with non-invasive pulse oximetry, there is evidence to suggest that co-oximetric blood gas analysis with several unique analyzers may be altered in the presence of hydroxocobalamin, specifically with false elevations of carboxyhemoglobin and methemoglobin concentrations and underestimation of true oxygen saturation values.5 There is no available evidence regarding the accuracy of other commonly utilized oximetric monitoring modalities (e.g., cerebral oximetry) following hydroxocobalamin administration

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Proc Natl Acad Sci USA 1995

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Comparing exposure from ingested amounts of an element to injected amounts of an element is scientific manipulation

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Li L, Li YW, Zhao JY, Liu YZ, Holscher C (2009) Quantitative analysis of iron concentration and expression of ferroportin 1 in the cortex and hippocampus of rats induced by cerebral ischemia

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In recent years, the pathophysiological mechanisms of early brain injury (EBI) after SAH have become the hotspot of experimental and clinical research, and EBI is the key factor of poor prognosis of SAH

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