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For instance, apoptosis-induced loss of serotonergic neurons can diminish serotonin availability, contributing to the onset of depressive symptoms

Fact: Dark circles are often caused by internal factors like melanin production, oxidative stress, and genetics, which is why topical creams alone often fail

Lancet 355 , 11791180 (2000)

It is important to bear in mind that the efficacy of zinc supplementation depends on factors like individual study characteristics, publication bias, sample size, interactions with other nutrients, differences in methodology, and timing of supplementation