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Prandial timing matters more for gastric modulators (amylin analogues, GLP-1 agonists) than for systemic metabolic agents

Using simple sterile water would mean the vial is only safe for a single use, as any introduction of a needle carries the risk of contamination that can then proliferate in the solution

Hughes, E., Wallender, E., Mohamed Ali, A., Jagannathan, P

Inject into the front or outer surface of the thigh, in the middle third between hip and knee

At the same dose, a 74 kg participant had about 1.4 times the exposure of a 110 kg reference, while a 143 kg participant had about 0.8 times. Weight alone does not set the dose, but it helps explain why the trial mean transfers poorly to bodies outside the studied range