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In fact, the STEP trials found that only 0.8-4.5% of participants stopped treatment because of digestive issues

Common side effects of GLP-1 drugs as a class include nausea, vomiting, diarrhea, constipation, stomach pain, and decreased appetite

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Notably, BUD13 immunoprecipitated WT F-SNIP1 more efficiently than the F-SNIP1 mutants, indicating a reduced ability of the mutants to associate with the activated spliceosome (Fig