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To apply, gently remove the patch from the backing and place it on a clean, dry, hair-free area of the skin (such as the upper arm or abdomen)

Such circadian dampening and phase shifts are thought to contribute to health issues in the elderly

Some older studies examined combinations of weaker GLP-1 drugs with DPP-4 inhibitors, showing modest additional glucose lowering compared to either drug alone, but the incremental benefit did not justify the added complexity and cost for most patients

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