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Results and discussion Epidemiology Accurately determining the incidence of idiosyncratic DILI is a significant challenge
symptoms: nausea, vomiting, abdominal pain, confusion, fruity breath) Dehydration and hypotension (risk factors: diuretic use, lowsalt diet, elderly, renal impairment) Lifethreatening allergic reactions (angioedema, anaphylaxis) Hypoglycemia when combined with insulin or sulfonylureas Pancreatitis (severe abdominal pain radiating to back, nausea, vomiting) Fourniers gangrene (necrotizing fasciitis of perineum) Monitoring and precautions Take Farxiga daily
Interleukin (IL)-23 and Th17 activation also induce keratinocyte proliferation and further release of pro-inflammatory cytokines in a positive feedback loop
