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Studies utilizing 'mini-brains' or organoids derived from patient stems cells, particularly those with MEF2C haploinsufficiency syndrome, have demonstrated excessive electrical activity and an imbalance between excitatory and inhibitory signaling

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4.3.2 Methodological limitations and clinical strategies Existing studies generally treat pregnancy-related outcomes as secondary or exploratory endpoints and seldom report analyses stratified by weight-loss achievement, insulin-resistance improvement, or washout structure (111, 112, 124)

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Models of Alzheimers disease: cellular and molecular aspects