Mortality rates were assessed by cross-referencing patient identification numbers with the Israeli National Population Registry
Then falls out
In the first sensitivity analysis comparing the risk of incident NAION in persons with T2D treated with SGLT2 inhibitors alone ( n = 40,206, reference), once-weekly semaglutide alone ( n = 71,658), and once-weekly semaglutide and SGLT2 inhibitors combined ( n = 45,401), we observed 6 events in 82,877 person-years, 36 events in 178,868 person-years, and 31 events in 119,106 person-years, respectively, corresponding to adjusted HR of 242 (95% CI 097 606) and 262 (95% CI 102674) for once-weekly semaglutide without and with SGLT2 inhibitors in a multivariable model adjusted for sex, age, marital status, duration of diabetes, hemoglobin A1c, estimated glomerular filtration rate, cardiovascular disease, use of insulin, use of cholesterol-lowering medicine, and use of blood pressure lowering medicine
Long-Term Safety : Berberine has been used for centuries, while semaglutides long-term effects are still being studied
The non-standard residues in its sequence (Aib, D-2-Nal, D-Phe) confer metabolic stability against peptidase degradation and constrain the bioactive conformation
