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doi: 10.2337/dci17-0057 224 HeineRJVan GaalLFJohnsDMihmMJWidelMHBrodowsRGet al

To address the high biological and technical variability inherent to metabolomics, each subclass was analyzed independently

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They probably have other psychological issues perhaps, or they stayed away from fitness and sports because they were never good at them or they were embarrassed to do it, so they don't have the skill set and the liking of being physically active