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In naturally aged rat ovaries, abnormal upregulation of transferrin (TF) and iron regulatory protein 2 (IRP2)-mediated transferrin receptor 1 (TfR1) leads to iron accumulation (Sze et al., 2022)

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On a molecular level, AOD-9604 is compact enough to achieve good solubility in aqueous diluents yet large enough to retain the structural motif needed for its adipocyte-targeting activity

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